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January 29, 2017

ALCOHOL - THE METABOLISM INHIBITOR



Alcohol is absorbed in the stomach and small intestines. Although it is a nutrient that provides 7 calories per gram. It must also be considered an antinutrient because of the way it inhibits the normal metabolism of vitamins, and therefore, the main energy substrates (carbohydrates, protein and fats) if consumed in excess. Most important, alcohol should not be mistaken for an essential nutrient, which it is not. It is a toxic substance that human have a limited capacity to detoxify, and in the process, alcohol leaves other toxic substances in its wake.




A regular high intake of alcohol increases disease risk, including cancers of lives, mouth, throat and esophagus (these latter three cancers are even more likely if combined with smoking) as well as cirrhosis of the liver (a condition where increasing portions of the liver become fibrotic and are no longer able to function). In addition, alcohol can be an irritant to all segments of the gastro-intestinal (GI) tract and, as a result, can cause the malabsorption of nutrients. To make matter worse, alcohol increases the urinary excretion of calcium and magnesium. Magnesium is a cofactor in enzymes transferring phosphate groups, so it is a needed ingredient in energy metabolism. Regular alcohol intake lowers the resorption of magnesium (increasing urinary losses) and also increases magnesium excretion in sweat. The result is an increase in muscle cramps, weakness, and cardiac arrhythmias.



Because liver function is also impaired, alcohol may also interfere with the normal metabolism and storage of nutrients. Further, alcohol increases nutrient requirements so as to repair the damage it creates and to counteract the malabsorption it produces. Chronic alcohol abuse may weaken the heart; alter brain and nerve function; increase blood lipids (triglycerides); result in a fatty, cirrhotic liver that malfunctions; and cause pancreatitis (which can have a major impact on blood glucose control and digestive processes). Besides the increased risk of muscular injury induced by alcohol consumption, there is also evidence that more than one drink per day can have a clear effect on performance by negatively affecting reaction time, coordination, and energy metabolism.

Alcohol dehydrogenase, a liver enzyme, is made by the liver to dehydrogenase the active form of vitamin A (retinol, an alcohol). However, with alcohol (ethanol) consumption, the limited production of alcohol dehydrogenase is shunted to dehydrogenate ethanol, thereby leaving the potentially toxic form of Vitamin A in the alcohol form. The result is an adverse interaction between alcohol and Vitamin A that can further result in liver toxicity and increased cancer risk.

Above is purely a science, but conclusion is very general. See it below.




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